ANTILEPROTIC DRUGS EBOOK

A Power point presentation on the Drugs used in Leprosy (Antileprotic Drugs) suitable for Undergraduate level Medical Students and also. Substances that suppress Mycobacterium leprae, ameliorate the clinical manifestations of leprosy, and/or reduce the incidence and severity of leprous reactions. Raghu Prasada. Sulfones – DAPSONE (DDS)-DIAMINO DIPHENYL SULFONE Phenazine Derivative - CLOFAZIMINE Antitubercular Drugs - RIFAMPICIN, ETHIONAMIDE Antibiotics: OFLOXACIN, MOXIFLOXACIN, MINOCYCLINE AND CLARITHROMYCIN. ANTI-TB AND ANTI LEPROTIC DRUGS [MEDICINAL CHEMISTRY] BY P.


ANTILEPROTIC DRUGS EBOOK

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ANTILEPROTIC DRUGS EBOOK


Main drugs used in chemotherapy of these diseases may inhibit the main lysosomal cysteine proteinases i.

ANTILEPROTIC DRUGS EBOOK

So the aim of this study is to see the effect of antileprotic drugs and antileprotic drugs on these proteolytic enzymes. The effect of commonly used antituberculous and antileprotic drugs was screened on the activities of purified antileprotic drugs lysosomal cysteine proteinases namely cathepsins B [EC 3.

Among the antileprotic drugs, only clofazimine inhibited the enzymic activities whereas dapsone had no effect whatsoever.

In antituberculous drugs, rifampicin was the most antileprotic drugs while isoniazid had little inhibitory potency. Streptomycin and pyrazinamide did not effect the activities at all. As regards the mechanism of inhibition, clofazimine and isoniazid inhibited the enzymes in a non-competitive manner with K values of 0.

Antileprotic drug (Concept Id: C)

Selected References These references are in PubMed. This may not be the complete list of references from this article. Intracellular distribution patterns of antileprotic drugs in rat liver tissue. Role of lysosome in cell-virus interaction. Lysosomes in Biology and Antileprotic drugs.

ANTILEPROTIC DRUGS EBOOK

Protein degradation in cultured cell-II: The uptake of chloroquine by rat fibroblast and the inhibition of antileprotic drugs protein degradation and cathepsin. Uptake of 3H -dihydrostreptomycin by macrophages in culture.

ANTILEPROTIC DRUGS EBOOK

An examination of the cytotoxic effects of silica on macrophages. Molecular basis of gouty inflammation: Interaction antileprotic drugs monosodium urate crystals with lysosomes and liposomes. Chemistry of Lysosomal Proteases.

Assessment of antioxidant activity of some antileprotic drugs.

Their role in protein breakdown. The concentration in inflamed skin is 10 to 15 times higher than that found in normal skin. The sulfones are retained in the circulation for a long time 12—35 days because of hepatobiliary drug recirculation. Dapsone, combined with other antileprosy antileprotic drugs like rifampicin and clofazimineis used in the treatment of both multibacillary antileprotic drugs paucibacillary M.

Assessment of antioxidant activity of some antileprotic drugs.

Dapsone is also used in the treatment and prevention of Pneumocystis carinii antileprotic drugs in AIDS patients who are allergic to or intolerant of trimethoprim—sulfamethoxazole. Acedapsone is a derivative of dapsone that has little activity against M.

It is a long-acting intramuscular repository form of dapsone with a half-life of 46 days. It may prove useful in leprosy patients who cannot tolerate long-term oral dapsone therapy. The sulfones can produce non- hemolytic anemia antileprotic drugs, methemoglobinemiaand sometimes acute hemolytic anemia in persons with a glucosephosphate dehydrogenase deficiency.

Within a few weeks of therapy some patients may develop acute skin lesions described as sulfone syndrome or dapsone dermatitis. Some rare side effects include fever, antileprotic drugsparesthesiaantileprotic drugs neuropathyand hepatotoxicity.

Leprostatic agent - Wikipedia

Clofazimine[ edit ] Clofazimine is a weakly bactericidal dye that has some activity against Antileprotic drugs. Its precise mechanism of action is unknown but may involve mycobacterial DNA binding.

Clofazimine achieves significant concentrations in tissues, including the phagocytic cells ; it has a plasma half-life of 70 days. Clofazimine is antileprotic drugs to treat sulfone-resistant leprosy or to patients who are intolerant to sulfones.